Endocrine Abstracts

Background: Incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NEMs) is increasing, but etiology of sporadic, non-familial disease remains obscure. Behavioral risk factors like smoking and alcohol consumption may be associated with GEP-NENs, yet environmental factors potentially associated with GEP-NENs remain unexamined. We regressed age-adjusted incidence rates for GEP-NENs cases in California (CA) on county-level pollution data to determine if an association ...

Background: Bone metastasis from gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) was once considered rare, but prevalence has recently been reported as high as 12%. Although bone metastasis has been associated with poor prognosis, the most frequent cause of mortality in this population remains liver failure when liver metastases are present. Thus, it remains unclear whether patients with concurrent liver and bone metastasis who receive liver directed therapy (LDT) w...